There is a discrepancy in the Gleason score given on the initial biopsy and prostatectomy specimen, respectively, that affects both patients who can benefit from active surveillance and those who cannot benefit from curative surgical treatment, and for whom therapeutic alternatives must be established.
In this context, our study aimed at analyzing the diagnostic concordance between biopsies and subsequent prostatectomies, in order to establish the accuracy of prostate biopsy in predicting final Gleason score of the prostatectomy specimens.
Material and methods: We analyzed 79 cases of PADK, initially diagnosed by prostate biopsy and subsequently treated by radical prostatectomy. The accuracy degree of the tumoral grading system assigned to the prostate biopsy, compared with the radical prostatectomy, was assessed by calculation of the Cohen's kappa concordance coefficient and calculation of sensitivity, specificity, positive prognostic value and negative prognostic value.
Results: 37 cases In prostate biopsies, 32 cases The lowest agreement rate was observed for Gleason score 5, where no case showed a similar score for biopsy and prostatectomy. Statistical analysis indicated a kappa coefficient of 0.
The agreement on ISUP prognostic grade groups between prostate biopsy and radical prostatectomy indicated a slight increase in kappa coefficient Conclusions: Our results demonstrate an increase in the predictive accuracy of prostate biopsy, as a result of the application of prognostic grade group system, which ensure the decrease of overestimating tendency of the old scoring system, ultimately leading to a preliminary characterization of potential lesions in prostatectomy specimens and a more effective treatment stratification of patients.
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Publicat în Cum să scapi rapid de prostatită? Men with more advanced or aggressive cancer are more likely to have a relapse after treatment. Relapse or recurrence is the return of cancer, requiring additional treatment. Gleason score given in the pathology report is expressing the grade of the prostate cancer. A GS of 7 is considered intermediate grade.
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Source: Acta Medica Transilvanica. The purpose of this study is represented by the clinical evaluation of the effectiveness of open radical retropubic prostatectomy with bilateral ilio-obturator lymph node dissection in patients with prostate cancer. We studied a group of patients who underwent open radical retropubic prostatectomy for prostate cancer in localized stage between January - February The average age of patients was Preoperative PSA level was between 2.
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Adenocarcinom prostata score gleason 7
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