However, the ciclesonide treatment arm had fewer subsequent emergency department visits or hospital admissions for reasons related to COVID odds ratio, 0. No participants died during the study. Lancet November 17, Lancet Rheumatology November 17, EClinical Medicine November 05, In the primary endpoint analysis, adjusted for baseline imbalance, the hazard ratio was 0. J Gen Intern Med November 9, 1— J Clin Invest November 15, Fluvastatin treatment specifically down-regulated proteins that modulate protein translation and viral replication.
The number needed to treat to prevent one hospitalization was among the lowest-risk patient group compared to NNT of 4 among those with the highest numbers of medical co-morbidities. Nat Med November 15, Dexamethasone also induced the emergence of immature neutrophils expressing ARG1 and ANXA1, genes encoding immunosuppressive molecules, which were absent in healthy controls.
Intravenous immunoglobulins in patients with COVIDassociated moderate-to-severe acute respiratory distress syndrome ICAR : multicentre, double-blind, placebo-controlled, phase 3 trial.
Lancet Respiratory Diseases, November 11, J Inf Dis, November 8, Nat Commun November 5,12, Nat Commun November12, Lancet Global Health October 27, There are several potential mechanisms in the treatment of COVID illness, including anti-inflammatory and possible antiviral effects.
Article Introduction Colorectal cancer CRC is the third most common cancer in men and the second most common in women.
In this large RCT from Brazil, treatment with fluvoxamine mg twice daily for 10 days among high-risk outpatients with early diagnosed COVID reduced the need for hospitalization. NEJM October 27, Notably, a mg dose may also permit intramuscular administration.
Rubin R. JAMA October 27, These people would qualify for a pre-exposure prophylaxis PREP.
Rita Rubin summarizes the problems and hurdles. Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.
Science Transl Medicine, October 20, Nat Commun 12, Using different experimental models as well as mathematical modeling, the authors demonstrate that COVA may work in vivo. NEJM October 20, Six of the 21 cases from August were hospitalized for toxic effects, including severe episodes of confusion, ataxia, seizures, and hypotension.
Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID a double-bind, randomised, placebo-controlled, phase 3 trial. Lancet Resp Med October 18, Wilkinson T. Another example?
Nat Commun 12,October 18,