Prostate cancer


prostatita trichomonasis ipsos de la prostatită angro

DOI: Myc-associated zinc-finger protein MAZ is a well-documented oncogene involved in the progression and metastasis prostate cancer multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone metastasis of PCa remain unclear.

Statistical analysis tratamentul prostatitei simptomatice performed to evaluate the clinical correlation between MAZ expression and clinicopathological features and bone metastasis-free survival in PCa patients.

Biological roles of MAZ in bone metastasis of PCa were investigated both in vitro by transwell assay, and in vivo by a mouse model of left cardiac ventricle inoculation.

moxifloxacina pentru tratamentul prostatitei tratamentul prostatitei cu rădăcină roșie

The bioinformatics analysis, western blot, pull-down assays, chromatin immunoprecipitation ChIP and luciferase reporter assays were applied to demonstrate and examine the relationship between MAZ and its potential downstream signalling pathway. TaqMan copy number assay was performed to identify the underlying mechanism responsible for MAZ overexpression in PCa tissues.

Results: MAZ expression is elevated in PCa tissues with bone metastasis compared with that in PCa tissues without bone metastasis, and is further increased in metastatic bone tissues.

prostatita de inot ce sa intepa din prostatita

High expression of MAZ positively correlates with poor overall and bone metastasis-free survival in PCa patients. Upregulating MAZ elevates, while silencing MAZ represses the invasion and migration abilities of PCa cells in vitro and bone metastasis ability in vivo.

Finally, our results indicate that recurrent gains contribute to MAZ overexpression in a prostate cancer portion of PCa tissues.

dacă este necesar să te protejezi cu prostatita la un bărbat cum să știi dacă există sau nu prostatită

MeSH terms.